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MGMT promoter methylation status in clival chordoma.
- Source :
-
Journal of neuro-oncology [J Neurooncol] 2014 Jun; Vol. 118 (2), pp. 271-276. Date of Electronic Publication: 2014 Apr 26. - Publication Year :
- 2014
-
Abstract
- Chordomas are rare, slow-growing neoplasms, characterized by locally aggressive growth patterns and high local recurrence rates. To the best of our knowledge, the MGMT promoter methylation status has not been studied in a population of patients with chordomas to determine if a biologic rationale exists to support the use of temozolomide. We here show for the first time that methylation of MGMT promoter is present in a significant portion or recurring clival chordomas; on the contrary in clival chordomas without recurrence MGMT promoter was always unmethylated (p = 0.0317). Although these observations need to be confirmed in a larger study population, our results (1) indicate that methylation of MGMT promoter is present in a significant portion of recurring chordomas, and (2) prompt further investigation into the potential role of temozolomide as an adjuvant treatment of these tumors.
- Subjects :
- Adult
Aged
Chordoma metabolism
Chordoma surgery
DNA Modification Methylases metabolism
DNA Mutational Analysis
DNA Repair Enzymes metabolism
Female
Follow-Up Studies
Humans
Immunohistochemistry
Isocitrate Dehydrogenase genetics
Male
Middle Aged
Neoplasm Recurrence, Local
Skull Base Neoplasms metabolism
Skull Base Neoplasms surgery
Tumor Suppressor Proteins metabolism
Chordoma genetics
Cranial Fossa, Posterior metabolism
Cranial Fossa, Posterior surgery
DNA Methylation
DNA Modification Methylases genetics
DNA Repair Enzymes genetics
Promoter Regions, Genetic
Skull Base Neoplasms genetics
Tumor Suppressor Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7373
- Volume :
- 118
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24771251
- Full Text :
- https://doi.org/10.1007/s11060-014-1445-y