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Chrotacumines G-J, chromone alkaloids from Dysoxylum acutangulum with osteoclast differentiation inhibitory activity.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Jun 01; Vol. 24 (11), pp. 2437-9. Date of Electronic Publication: 2014 Apr 13. - Publication Year :
- 2014
-
Abstract
- Four new chromone alkaloids, chrotacumines G-J (1-4), have been isolated from the barks of Dysoxylum acutangulum. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Chrotacumines G and J (1 and 4) showed osteoclast differentiation inhibitory activity in a dose dependent manner.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Alkaloids chemistry
Alkaloids isolation & purification
Cell Differentiation drug effects
Chromones chemistry
Chromones isolation & purification
Dose-Response Relationship, Drug
Humans
Molecular Structure
Osteoclasts cytology
Piperidines chemistry
Piperidines isolation & purification
Plant Bark chemistry
Structure-Activity Relationship
Alkaloids pharmacology
Chromones pharmacology
Meliaceae chemistry
Osteoclasts drug effects
Piperidines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 24
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 24767841
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.04.020