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Targeting mycobacterial proteolytic complexes with natural products.

Authors :
Parish T
Source :
Chemistry & biology [Chem Biol] 2014 Apr 24; Vol. 21 (4), pp. 437-438.
Publication Year :
2014

Abstract

Controlled proteolysis is key to bacterial viability. In this issue of Chemistry & Biology, Gavrish and colleagues characterize a natural product, lassomycin, targeting the Mycobacterium tuberculosis caseinolytic (Clp) protease. Unusually, lassomycin activates ClpC1, inducing ATPase activity and decoupling it from proteolysis.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Subjects

Subjects :
ATP-Dependent Proteases antagonists & inhibitors
Anti-Bacterial Agents pharmacology
Mycobacterium tuberculosis drug effects
Peptides, Cyclic pharmacology
Protease Inhibitors pharmacology

Details

Language :
English
ISSN :
1879-1301
Volume :
21
Issue :
4
Database :
MEDLINE
Journal :
Chemistry & biology
Publication Type :
Academic Journal
Accession number :
24766844
Full Text :
https://doi.org/10.1016/j.chembiol.2014.04.002
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