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Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity.
- Source :
-
Respiratory research [Respir Res] 2014 Apr 27; Vol. 15, pp. 53. Date of Electronic Publication: 2014 Apr 27. - Publication Year :
- 2014
-
Abstract
- Objectives: We aimed to explore the association between vitamin D levels and the severity, mortality and microbiological etiology of community-acquired pneumonia.<br />Methods: Vitamin D levels (both, the reservoir form 25-OH and the activated form 1,25-OH2) of 300 randomly selected patients with community-acquired pneumonia due to pre-specified pathogens included in the German competence network (CAPNETZ) study were measured. Prior to statistical analysis, values of 25-OH and 1,25-OH2 were power-transformed to achieve parametric distribution. All further analyses were performed with seasonally and age adjusted values.<br />Results: There was only a modest (Spearman Coefficient 0.38) positive correlation between 25-OH and 1,25-OH2. For 1,25-OH2 but not 25-OH, the general linear model revealed a significant inverse correlation between serum concentration and CURB score (p = 0.011). Liver and respiratory co-morbidity were associated with significantly lower 25-OH values and renal co-morbidity with significantly lower 1,25-OH2 values. No significant differences of 1,25-OH2 or 25-OH between different pathogens (influenza virus, Legionella spp., Streptococcus pneumoniae) were detected.<br />Conclusion: For 1,25-OH2, we found a significant and independent (controlled for age, season and pathogen) negative correlation to pneumonia severity. Therefore, supplementation of non-activated vitamin D to protect from pneumonia may be non-sufficient in patients that have a decreased capacity to hydroxylate 25-OH to 1,25-OH2.
- Subjects :
- Adult
Aged
Biomarkers blood
Cohort Studies
Community-Acquired Infections blood
Community-Acquired Infections diagnosis
Community-Acquired Infections epidemiology
Cross-Sectional Studies
Dihydrotachysterol blood
Female
Humans
Male
Middle Aged
Pneumonia diagnosis
Pneumonia epidemiology
Prospective Studies
Vitamin D blood
Vitamin D Deficiency diagnosis
Vitamin D Deficiency epidemiology
Dihydrotachysterol analogs & derivatives
Pneumonia blood
Seasons
Severity of Illness Index
Vitamin D Deficiency blood
Subjects
Details
- Language :
- English
- ISSN :
- 1465-993X
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Respiratory research
- Publication Type :
- Academic Journal
- Accession number :
- 24766747
- Full Text :
- https://doi.org/10.1186/1465-9921-15-53