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Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers.
- Source :
-
Gut [Gut] 2015 Feb; Vol. 64 (2), pp. 292-302. Date of Electronic Publication: 2014 Apr 24. - Publication Year :
- 2015
-
Abstract
- Background and Objective: Precore (PC) variant (G1896A) and basal core promoter (BCP) variant (A1762T/G1764A) of HBV are associated with risk of hepatocellular carcinoma in HBV carriers. However, little is known about their impact on the adverse outcomes of hepatitis B e antigen (HBeAg)-negative hepatitis and liver cirrhosis.<br />Methods: 251 spontaneous HBeAg seroconverters who had genotype B or C infection and received a long-term follow-up were enrolled. PC and BCP mutants were determined qualitatively and quantitatively to correlate with these adverse outcomes. The findings were validated by an independent case-control study, which included 184 patients with biopsy-proven liver fibrosis stages.<br />Results: In the longitudinal cohort study, BCP mutant and possibly PC wild type were associated with cirrhosis development, but not HBeAg-negative hepatitis. Multivariable analysis showed that only BCP mutant was an independent risk factor for cirrhosis development. Using quantitative analysis of BCP mutant, a higher proportion of BCP mutant, defined as a continuous variable, a dichotomous variable or an ordinal variable, was associated with a higher risk of cirrhosis. If we chose 45% of BCP mutant as the cut-off, the risk of cirrhosis was higher in patients with BCP mutant ≥45% compared to <45% in the longitudinal cohort; this finding was validated by the case-control study (adjusted OR: 2.81, 95% CI 1.40 to 5.67).<br />Conclusions: A higher proportion of BCP mutant increases the risk of liver cirrhosis development in HBV carriers with genotype B or C infection.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
- Subjects :
- Adult
Carrier State
Case-Control Studies
DNA, Viral blood
Female
Hepatitis B complications
Hepatitis B Core Antigens blood
Hepatitis B virus classification
Hepatitis B virus immunology
Hepatitis B virus isolation & purification
Humans
Longitudinal Studies
Male
Middle Aged
Mutation
Risk Factors
Hepatitis B virology
Hepatitis B Core Antigens genetics
Hepatitis B virus genetics
Liver Cirrhosis virology
Promoter Regions, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1468-3288
- Volume :
- 64
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Gut
- Publication Type :
- Academic Journal
- Accession number :
- 24763132
- Full Text :
- https://doi.org/10.1136/gutjnl-2014-306977