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Acanthosis nigricans in obese Chinese children.
- Source :
-
Hong Kong medical journal = Xianggang yi xue za zhi [Hong Kong Med J] 2014 Aug; Vol. 20 (4), pp. 290-6. Date of Electronic Publication: 2014 Apr 25. - Publication Year :
- 2014
-
Abstract
- OBJECTIVES. To investigate the demographic characteristics and insulin resistance in local overweight/obese Chinese children with and without acanthosis nigricans, and the associations of acanthosis nigricans with insulin resistance and other cardiometabolic co-morbidities. DESIGN. Case series with cross-sectional analyses. SETTING. A regional hospital in Hong Kong. PATIENTS. Chinese children assessed between January 2006 and December 2010 at Tseung Kwan O Hospital for being overweight or obese. MAIN OUTCOME MEASURES. The demographics, anthropometric data, acanthosis nigricans status, and biochemical results were analysed. RESULTS. A total of 543 overweight/obese children were studied with 64% being boys and 29% had insulin resistance. Adolescents aged 12 to 18 years, compared with children aged 5 to 11 years, were more likely to have acanthosis nigricans (63% vs 47%; P<0.001) and insulin resistance (37% vs 25%; P=0.005). Compared with overweight children, those who were obese were more likely to have the two conditions: acanthosis nigricans (59% vs 44%; P=0.005) and insulin resistance (35% vs 19%; P=0.001). Compared with those without acanthosis nigricans, those with the condition had significantly higher mean values for systolic blood pressures (P<0.001), 2-hour post-oral glucose tolerance test glucose level (P=0.021), fasting insulin level (P<0.001), homeostasis model of assessment-insulin resistance (P<0.001), fasting triglyceride level (P<0.001), and alanine aminotransferase level (P=0.002), but a lower high-density lipoprotein cholesterol level (P<0.001). Those with acanthosis nigricans were also more likely to have insulin resistance (P<0.001), hypertension (P=0.021), fatty liver (P=0.001), and abnormal glucose homeostasis (P=0.003). CONCLUSION. Obese Chinese children and adolescents with acanthosis nigricans had a higher chance of having insulin resistance and cardiometabolic co-morbidities. Acanthosis nigricans is an important clinical feature warranting early attention and evaluation to facilitate timely interventions and monitoring.
- Subjects :
- Acanthosis Nigricans epidemiology
Acanthosis Nigricans pathology
Adolescent
Asian People
Cardiovascular Diseases epidemiology
Child
Child, Preschool
Cross-Sectional Studies
Female
Glucose Tolerance Test
Hong Kong epidemiology
Humans
Male
Metabolic Diseases epidemiology
Retrospective Studies
Acanthosis Nigricans complications
Insulin Resistance
Overweight complications
Pediatric Obesity complications
Subjects
Details
- Language :
- English
- ISSN :
- 1024-2708
- Volume :
- 20
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Hong Kong medical journal = Xianggang yi xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 24762331
- Full Text :
- https://doi.org/10.12809/hkmj134071