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Effect of magnesium oxide on interfraction prostate motion and rectal filling in prostate cancer radiotherapy: analysis of a randomized clinical trial.
- Source :
-
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2014 Aug; Vol. 190 (8), pp. 758-61. Date of Electronic Publication: 2014 Apr 24. - Publication Year :
- 2014
-
Abstract
- Purpose: To investigate whether magnesium oxide reduces the interfraction motion of the prostate and the amount of rectal filling and rectal gas, which influences prostate position during radiotherapy for prostate cancer.<br />Patients and Methods: From December 2008 to February 2010, 92 prostate cancer patients scheduled for intensity-modulated radiotherapy (77 Gy in 35 fractions) using fiducial marker-based position verification were randomly assigned to receive magnesium oxide (500 mg twice a day) or placebo during radiotherapy. In a previous study, we investigated the effect on intrafraction motion and did not find a difference between the treatment arms. Here, we compared the interfraction prostate motion between the two treatment arms as well as the amount of rectal filling and rectal air pockets using pretreatment planning computed tomography and magnetic resonance imagingscans.<br />Results: There was no statistically significant difference between the treatment arms in translation and rotation of the prostate between treatment fractions, except for the rotation around the cranial caudal axis. However, the difference was less than 1° and therefore considered not clinically relevant. There was no significant difference in the amount of rectal filling and rectal air pockets between the treatment arms.<br />Conclusion: Magnesium oxide is not effective in reducing the interfraction prostate motion or the amount of rectal filling and rectal gas during external-beam radiotherapy. Therefore, magnesium oxide is not recommended in clinical practice for these purposes.
- Subjects :
- Aged
Dose Fractionation, Radiation
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Radiotherapy Planning, Computer-Assisted
Tomography, X-Ray Computed
Fiducial Markers
Laxatives
Magnesium Oxide administration & dosage
Motion
Patient Positioning
Prostatic Neoplasms radiotherapy
Radiotherapy, Intensity-Modulated methods
Subjects
Details
- Language :
- English
- ISSN :
- 1439-099X
- Volume :
- 190
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
- Publication Type :
- Academic Journal
- Accession number :
- 24760248
- Full Text :
- https://doi.org/10.1007/s00066-014-0660-y