Back to Search
Start Over
Development and evaluation of an open-source software package "CGITA" for quantifying tumor heterogeneity with molecular images.
- Source :
-
BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 248505. Date of Electronic Publication: 2014 Mar 17. - Publication Year :
- 2014
-
Abstract
- Background: The quantification of tumor heterogeneity with molecular images, by analyzing the local or global variation in the spatial arrangements of pixel intensity with texture analysis, possesses a great clinical potential for treatment planning and prognosis. To address the lack of available software for computing the tumor heterogeneity on the public domain, we develop a software package, namely, Chang-Gung Image Texture Analysis (CGITA) toolbox, and provide it to the research community as a free, open-source project.<br />Methods: With a user-friendly graphical interface, CGITA provides users with an easy way to compute more than seventy heterogeneity indices. To test and demonstrate the usefulness of CGITA, we used a small cohort of eighteen locally advanced oral cavity (ORC) cancer patients treated with definitive radiotherapies.<br />Results: In our case study of ORC data, we found that more than ten of the current implemented heterogeneity indices outperformed SUVmean for outcome prediction in the ROC analysis with a higher area under curve (AUC). Heterogeneity indices provide a better area under the curve up to 0.9 than the SUVmean and TLG (0.6 and 0.52, resp.).<br />Conclusions: CGITA is a free and open-source software package to quantify tumor heterogeneity from molecular images. CGITA is available for free for academic use at http://code.google.com/p/cgita.
- Subjects :
- Adult
Algorithms
Female
Humans
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Software Design
User-Computer Interface
Image Interpretation, Computer-Assisted methods
Internet
Molecular Imaging methods
Mouth Neoplasms diagnosis
Pattern Recognition, Automated methods
Positron-Emission Tomography methods
Software
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2014
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 24757667
- Full Text :
- https://doi.org/10.1155/2014/248505