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Paget's disease of bone.
- Source :
-
QJM : monthly journal of the Association of Physicians [QJM] 2014 Nov; Vol. 107 (11), pp. 865-9. Date of Electronic Publication: 2014 Apr 21. - Publication Year :
- 2014
-
Abstract
- Paget's disease of bone is a common disorder characterized by increased but disorganized bone remodelling. Some patients are asymptomatic but others present with bone pain or other complications such as fracture and deformity. Major advances have been made in understanding the pathophysiology of Paget's disease in recent years and highly effective agents are now available with which to suppress the abnormal bone turnover that causes the disease. Here we review recent advances in the epidemiology, pathogenesis, clinical features and management of Paget's disease. We also reflect upon the future challenges that remain to be overcome to explain the unusual distribution of the disease and to favourably alter the natural history and prevent the development of complications.<br /> (© The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Adaptor Proteins, Signal Transducing genetics
Bone Density Conservation Agents therapeutic use
Bone Remodeling physiology
Environmental Exposure adverse effects
Forecasting
Fractures, Spontaneous etiology
Genetic Predisposition to Disease genetics
Humans
Musculoskeletal Pain etiology
Mutation genetics
Osteoprotegerin genetics
Practice Guidelines as Topic
Receptor Activator of Nuclear Factor-kappa B genetics
Sequestosome-1 Protein
Osteitis Deformans diagnosis
Osteitis Deformans etiology
Osteitis Deformans therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2393
- Volume :
- 107
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- QJM : monthly journal of the Association of Physicians
- Publication Type :
- Academic Journal
- Accession number :
- 24757095
- Full Text :
- https://doi.org/10.1093/qjmed/hcu075