Back to Search
Start Over
Iron mapping using the temperature dependency of the magnetic susceptibility.
- Source :
-
Magnetic resonance in medicine [Magn Reson Med] 2015 Mar; Vol. 73 (3), pp. 1282-8. Date of Electronic Publication: 2014 Apr 17. - Publication Year :
- 2015
-
Abstract
- Purpose: The assessment of iron content in brain white matter (WM) is of high importance for studying neurodegenerative diseases. While R2 * mapping and quantitative susceptibility mapping is suitable for iron mapping in gray matter, iron mapping in WM still remains an unsolved problem. We propose a new approach for iron mapping, independent of diamagnetic contributions of myelin by assessing the temperature dependency of the paramagnetic susceptibility.<br />Theory and Methods: We used unfixed human brain slices for relaxometry and calculated R2 ' as a measure for microscopic susceptibility variations at several temperatures (4°C-37°C) at 3 Tesla. The temperature coefficient of R2 ' (TcR2p) was calculated by linear regression and related to the iron concentration found by subsequent superconducting quantum interference device (SQUID) magnetometry and by inductively coupled plasma mass spectrometry.<br />Results: In line with SQUID measurements, R2 ' mapping showed a linear temperature dependency of the bulk susceptibility with the highest slope in gray matter. Even in WM, TcR2p yielded a high linear correlation with the absolute iron concentration.<br />Conclusion: According to Curie's law, only paramagnetic matter exhibits a temperature dependency while the diamagnetism shows no effect. We have demonstrated that the temperature coefficient (TcR2p) can be used as a measure of the paramagnetic susceptibility despite of an unknown diamagnetic background.<br /> (© 2014 Wiley Periodicals, Inc.)
- Subjects :
- Aged
Algorithms
Brain Chemistry
Cadaver
Female
Humans
Magnetic Fields
Male
Reproducibility of Results
Sensitivity and Specificity
Tissue Distribution
White Matter ultrastructure
Image Interpretation, Computer-Assisted methods
Iron analysis
Iron chemistry
Magnetic Resonance Imaging methods
Thermography methods
White Matter chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2594
- Volume :
- 73
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Magnetic resonance in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24752873
- Full Text :
- https://doi.org/10.1002/mrm.25236