Studying aging in Drosophila.

Authors :: He Y
Jasper H
Source :: Methods (San Diego, Calif.) [Methods] 2014 Jun 15; Vol. 68 (1), pp. 129-33. Date of Electronic Publication: 2014 Apr 18.
Publication Year :: 2014
Abstract: Drosophila melanogaster represents one of the most important genetically accessible model organisms for aging research. Studies in flies have identified single gene mutations that influence lifespan and have characterized endocrine signaling interactions that control homeostasis systemically. Recent studies have focused on the effects of aging on specific tissues and physiological processes, providing a comprehensive picture of age-related tissue dysfunction and the loss of systemic homeostasis. Here we review methodological aspects of this work and highlight technical considerations when using Drosophila to study aging and age-related diseases.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)