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Periodontitis in cardiovascular disease patients with or without Marfan syndrome--a possible role of Prevotella intermedia.
- Source :
-
PloS one [PLoS One] 2014 Apr 18; Vol. 9 (4), pp. e95521. Date of Electronic Publication: 2014 Apr 18 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Background: Although periodontitis is a risk factor for cardiovascular disease (CVD), the influence of periodontitis on Marfan syndrome (MFS) with CVD is unclear. The aim of this study was to assess the relationship between periodontal bacterial burden and MSF with CVD.<br />Methods and Results: The subjects were patients with MFS with CVD (nā=ā47); age and gender matched non-MFS CVD patients (nā=ā48) were employed as controls. Full-mouth clinical measurements, including number of teeth, probing of pocket depth (PD), bleeding on probing (BOP) and community periodontal index (CPI) were recorded. We also evaluated the existence of three periodontal pathogens, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia using polymerase chain reaction assays. Serum antibody titers against the pathogens were also measured. We revealed that MFS with CVD patients had periodontitis more frequently than the age and gender matched non-MFS CVD control subjects. MFS with CVD patients had significantly severer periodontitis, fewer remaining teeth and deeper PD compared to the non-MFS CVD controls. Furthermore, the serum antibody titer level against Prevotella intermedia was significantly lower in MFS plus CVD patients compared to the non-MFS CVD patients.<br />Conclusion: Periodontitis may influence the pathophysiology of cardiovascular complications in MFS patients. A specific periodontal pathogen might be a crucial therapeutic target to prevent CVD development.
- Subjects :
- Adult
Antibodies, Bacterial blood
Antibodies, Bacterial immunology
Bacteroidaceae Infections immunology
Bacteroidaceae Infections microbiology
C-Reactive Protein metabolism
Female
Humans
Male
Natriuretic Peptide, Brain blood
Periodontitis diagnosis
Periodontitis microbiology
Prevotella intermedia genetics
Prevotella intermedia immunology
Cardiovascular Diseases complications
Cardiovascular Diseases etiology
Marfan Syndrome complications
Periodontitis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 24748407
- Full Text :
- https://doi.org/10.1371/journal.pone.0095521