[Oncolytic properties of some orthopoxviruses, adenoviruses and parvoviruses in human glioma cells].

Unlabelled: Currently one of the most promising approaches in development of cancer virotherapy is based on the ability of oncolytic viruses to selective infection and lysis of tumor cells.
Aim: The goal of the study was to identify and evaluate perspective oncolytic viruses capable of selectively destroying human glioma cells.
Patients and Methods: Original GB2m, GA14m and GB22m glioma cell cultures derived from patients were used for evaluating in vitro oncolytic activity of some typical orthopoxviruses, adenoviruses and parvoviruses.
Results: The oncolytic activity in the human glioma cell models was confirmed for LIVP and WR strains of vaccinia virus, Adel2 and Ad2del strains with deletions within E1B/55K gene and derived from human adenoviruses type 2 and 5, respectively.
Conclusions: We consider these oncolytic viruses as promising agents for the treatment of human malignant glioma.