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Hypothalamic sidedness in mitochondrial metabolism: new perspectives.

Authors :
Toth I
Kiss DS
Goszleth G
Bartha T
Frenyo LV
Naftolin F
Horvath TL
Zsarnovszky A
Source :
Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2014 Dec; Vol. 21 (12), pp. 1492-8. Date of Electronic Publication: 2014 Apr 16.
Publication Year :
2014

Abstract

Morphofunctional changes in hypothalamic neurons are highly energy dependent and rely on mitochondrial metabolism. Therefore, mitochondrial adenosine triphosphate production plays a permissive role in hypothalamic regulatory events. Here, we demonstrated that in the female rat hypothalamus, mitochondrial metabolism and tissue oxygenation show an asymmetric lateralization during the estrous cycle. This asymmetry was not detected in males. The observed sidedness suggests that estrous cycle-linked hypothalamic functions in females are based on hemispheric distinction. The novel concept of hypothalamic asymmetry necessitates the revision of hypothalamic neural circuits, synaptic reorganization, and the role of hypothalamic sides in the regulation of integrated homeostatic functions.<br /> (© The Author(s) 2014.)

Details

Language :
English
ISSN :
1933-7205
Volume :
21
Issue :
12
Database :
MEDLINE
Journal :
Reproductive sciences (Thousand Oaks, Calif.)
Publication Type :
Academic Journal
Accession number :
24740989
Full Text :
https://doi.org/10.1177/1933719114530188