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Indolicidin binding induces thinning of a lipid bilayer.
- Source :
-
Biophysical journal [Biophys J] 2014 Apr 15; Vol. 106 (8), pp. L29-31. - Publication Year :
- 2014
-
Abstract
- We use all-atom molecular dynamics simulations on a massive scale to compute the standard binding free energy of the 13-residue antimicrobial peptide indolicidin to a lipid bilayer. The analysis of statistical convergence reveals systematic sampling errors that correlate with reorganization of the bilayer on the microsecond timescale and persist throughout a total of 1.4 ms of sampling. Consistent with experimental observations, indolicidin induces membrane thinning, although the simulations significantly overestimate the lipophilicity of the peptide.<br /> (Copyright © 2014 Biophysical Society. Published by Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1542-0086
- Volume :
- 106
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Biophysical journal
- Publication Type :
- Academic Journal
- Accession number :
- 24739184
- Full Text :
- https://doi.org/10.1016/j.bpj.2014.02.031