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Poor prognosis of ovarian cancer with large cell neuroendocrine carcinoma: case report and review of published works.
- Source :
-
The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2014 Mar; Vol. 40 (3), pp. 869-72. - Publication Year :
- 2014
-
Abstract
- Large cell neuroendocrine carcinoma (LCNEC) is well-reported to result in unfavorable prognoses in many organ cancers while being rarely reported in gynecologic cancer, especially ovarian and endometrial cancers. Here we report a case of ovarian cancer with LCNEC which spread to distant organs within 1 year of primary surgery despite the fact that the post-surgical stage was Ia. The case received platinum-based chemotherapy as an adjuvant therapy after her curative surgery. However, LCNEC in the case was resistant to the chemotherapy. In our review of published works, ovarian cancer cases with LCNEC show poor prognoses regardless of adjuvant chemotherapy following complete resection. Median overall survival was 10 months in stage I cases. Development of chemotherapy sensitive for LCNEC is needed.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Large Cell pathology
Carcinoma, Large Cell secondary
Carcinoma, Large Cell therapy
Carcinoma, Neuroendocrine drug therapy
Carcinoma, Neuroendocrine pathology
Carcinoma, Neuroendocrine surgery
Chemotherapy, Adjuvant
Fatal Outcome
Female
Humans
Kaplan-Meier Estimate
Middle Aged
Neoplasm Staging
Ovarian Neoplasms pathology
Ovarian Neoplasms secondary
Ovarian Neoplasms therapy
Prognosis
Carcinoma, Large Cell diagnosis
Carcinoma, Neuroendocrine diagnosis
Drug Resistance, Neoplasm
Ovarian Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1447-0756
- Volume :
- 40
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The journal of obstetrics and gynaecology research
- Publication Type :
- Academic Journal
- Accession number :
- 24738132
- Full Text :
- https://doi.org/10.1111/jog.12235