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Improvement of microcirculation and wound healing in vertical ridge augmentation after pre-treatment with self-inflating soft tissue expanders - a randomized study in dogs.
- Source :
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Clinical oral implants research [Clin Oral Implants Res] 2015 Jun; Vol. 26 (6), pp. 720-4. Date of Electronic Publication: 2014 Apr 16. - Publication Year :
- 2015
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Abstract
- Objectives: We investigated the effect of soft tissue expansion (STE) on vertical ridge augmentation with regard to the incidence of wound dehiscences and the impairment of microcirculation in dogs, and the applicability of laser Doppler flowmetry (LDF) to explore the relation between microcirculation and wound healing.<br />Material and Methods: Bone defects were created on both mandibular sides in ten beagle dogs by extraction of premolars and removal of bone. Six weeks later, self-filling tissue expanders were implanted in randomly assigned test sites. After 5 weeks of expansion, vertical augmentation was carried out in test and control sites using calvarial onlay grafts side by side with granular biphasic calcium phosphate covered with a resorbable polyethylene glycol membrane. Microcirculation was evaluated with laser Doppler flowmetry (LDF). The incidence of wound dehiscences was evaluated after 2 weeks. The validity of LDF to predict dehiscences was evaluated by construction of receiver operating characteristic (ROC) curves.<br />Results: After augmentation, test sites showed significantly better perfusion than control sites without preceding STE (P = 0.012). Three days after surgery, perfusion was still significantly decreased in control sites (P = 0.005), while microcirculation in test sites had returned to pre-surgical levels. After 2 weeks, healing in test sites was good, whereas eight dehiscences were found in control sites (P = 0.002). ROC curves showed that microcirculation levels immediately after augmentation surgery significantly predicted subsequent wound dehiscences (AUC = 0.799, CI 0.642-0.955, P = 0.006).<br />Conclusions: Laser Doppler flowmetry is suitable for evaluation of soft tissue microcirculation after ridge augmentation. STE reduced the impairment of microcirculation caused by vertical ridge augmentation and decreased the incidence of wound dehiscences in the investigated animal model.<br /> (© 2014 The Authors. Clinical Oral Implants Research Published by John Wiley & Sons Ltd.)
- Subjects :
- Alveolar Process surgery
Animals
Bone Regeneration drug effects
Bone Substitutes pharmacology
Bone Transplantation
Dental Implantation, Endosseous
Dogs
Hydroxyapatites therapeutic use
Laser-Doppler Flowmetry methods
Surgical Wound Dehiscence surgery
Alveolar Process blood supply
Alveolar Ridge Augmentation methods
Guided Tissue Regeneration, Periodontal methods
Microcirculation physiology
Tissue Expansion methods
Tissue Expansion Devices
Wound Healing physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0501
- Volume :
- 26
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical oral implants research
- Publication Type :
- Academic Journal
- Accession number :
- 24735431
- Full Text :
- https://doi.org/10.1111/clr.12377