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Avirulent strains of Toxoplasma gondii infect macrophages by active invasion from the phagosome.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Apr 29; Vol. 111 (17), pp. 6437-42. Date of Electronic Publication: 2014 Apr 14. - Publication Year :
- 2014
-
Abstract
- Unlike most intracellular pathogens that gain access into host cells through endocytic pathways, Toxoplasma gondii initiates infection at the cell surface by active penetration through a moving junction and subsequent formation of a parasitophorous vacuole. Here, we describe a noncanonical pathway for T. gondii infection of macrophages, in which parasites are initially internalized through phagocytosis, and then actively invade from within a phagosomal compartment to form a parasitophorous vacuole. This phagosome to vacuole invasion (PTVI) pathway may represent an intermediary link between the endocytic and the penetrative routes for host cell entry by intracellular pathogens. The PTVI pathway is preferentially used by avirulent strains of T. gondii and confers an infectious advantage over virulent strains for macrophage tropism.
- Subjects :
- Animals
Cell Line
Macrophages pathology
Macrophages ultrastructure
Mice
Mice, Inbred C57BL
Phagocytosis
Phagosomes pathology
Phagosomes ultrastructure
Toxoplasma ultrastructure
Toxoplasmosis parasitology
Toxoplasmosis pathology
Tropism
Vacuoles parasitology
Vacuoles pathology
Vacuoles ultrastructure
Macrophages parasitology
Phagosomes parasitology
Toxoplasma pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 111
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 24733931
- Full Text :
- https://doi.org/10.1073/pnas.1316841111