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Association of age and BP variability with long-term mortality in hemodialysis patients.
- Source :
-
Kidney & blood pressure research [Kidney Blood Press Res] 2013; Vol. 38 (2-3), pp. 172-80. Date of Electronic Publication: 2014 Apr 08. - Publication Year :
- 2013
-
Abstract
- Background/aims: Blood pressure (BP) variability is known as a poor prognostic factor for cardiovascular outcomes. This study assessed the prognostic significance of BP variability in association with increasing age in hemodialysis patients.<br />Methods: We retrospectively analyzed 2,174 patients on hemodialysis from March 2005 to December 2012. The impact of intradialytic and interdialytic BP variability on all-cause mortality according to age groups was analyzed.<br />Results: Kaplan-Meier survival curves for 5-year cumulative mortality showed higher mortality in patients with higher intradialytic systolic and diastolic BP variability as well as interdialytic systolic and diastolic BP variability (log-rank p=0.006, <0.001, 0.018 and < 0.001) in patients aged <55 years, but not in older age groups. Cox proportional analysis revealed that 5-year mortality was associated with intradialytic diastolic BP variability in patients aged <55 years (HR, 2.03 CI, 1.24-3.32).<br />Conclusion: The overall mortality was associated with BP variability in patients aged <55 years, but not in older ages. This result suggests that younger hemodialysis patients with BP variability require further medical attention and intervention to reduce BP variability.
Details
- Language :
- English
- ISSN :
- 1423-0143
- Volume :
- 38
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Kidney & blood pressure research
- Publication Type :
- Academic Journal
- Accession number :
- 24731993
- Full Text :
- https://doi.org/10.1159/000355765