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High-throughput screening of metal-N-heterocyclic carbene complexes against biofilm formation by pathogenic bacteria.
- Source :
-
ChemMedChem [ChemMedChem] 2014 Jun; Vol. 9 (6), pp. 1140-4. Date of Electronic Publication: 2014 Apr 11. - Publication Year :
- 2014
-
Abstract
- A set of molecules including a majority of metal-N-heterocyclic carbene (NHC) complexes (metal=Ag, Cu, and Au) and azolium salts were evaluated by high-throughput screening of their activity against biofilm formation associated with pathogenic bacteria. The anti-planktonic effects were compared in parallel. Representative biofilm-forming strains of various genera were selected (Listeria, Pseudomonas, Staphylococcus, and Escherichia). All the compounds were tested at 1 mg L(-1) by using the BioFilm Ring Test. An information score (IS, sum of the activities) and an activity score (AS, difference between anti-biofilm and anti-planktonic activity) were determined from normalized experimental values to classify the most active molecules against the panel of bacterial strains. With this method we identified lipophilic Ag(I) and Cu(I) complexes possessing aromatic groups on the NHC ligand as the most efficient at inhibiting biofilm formation.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Anti-Bacterial Agents pharmacology
Biofilms growth & development
Coordination Complexes pharmacology
Copper chemistry
Gold chemistry
Gram-Negative Bacteria physiology
Gram-Positive Bacteria physiology
Methane chemistry
Microbial Sensitivity Tests
Silver chemistry
Anti-Bacterial Agents chemistry
Biofilms drug effects
Coordination Complexes chemistry
Heterocyclic Compounds chemistry
Methane analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1860-7187
- Volume :
- 9
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- ChemMedChem
- Publication Type :
- Academic Journal
- Accession number :
- 24729552
- Full Text :
- https://doi.org/10.1002/cmdc.201402012