Back to Search
Start Over
Skeletal-related events and mortality among older men with advanced prostate cancer.
- Source :
-
Journal of geriatric oncology [J Geriatr Oncol] 2014 Jul; Vol. 5 (3), pp. 281-9. Date of Electronic Publication: 2014 Apr 14. - Publication Year :
- 2014
-
Abstract
- Objective: Skeletal-related events (SREs) are defined as a cluster of events including clinical diagnoses and treatment. Using claims data, the burden of SREs as a group has been reported among patients with cancer. We investigate the mortality impact of subcomponents of SREs, a topic that has received limited attention among older men.<br />Materials and Methods: We analyzed prostate cancer (PCa) and all-cause mortality among men diagnosed with metastatic PCa from 2000 to 2007 using Surveillance, Epidemiology, and End Results data linked with 1999-2009 Medicare data. We created three measures of pathological fracture (PF), spinal cord compression (SCC), and bone surgery (BS) that differed in the use of claims-based bone metastasis information. We reported covariate-adjusted hazard ratios (HRs) using the full sample and a propensity score-matched sample (PSMS).<br />Results: Application of inclusion/exclusion criteria resulted in 7062 men in the full sample (1776 in the PSMS). PCa-specific (all-cause mortality) was 54% (80%) at a median follow-up of 609days. SRE prevalence ranged from 9.7% to 17.1% across the measures. In a PCa mortality model, the HR associated with an SRE ranged from 1.07 (0.98-1.16) to 1.31 (1.18-1.45). The HRs for SCC and PF were statistically significant and positively associated with PCa-specific mortality. The results for BS depended on the measure. Results for SCC and BS, but not for PF, were preserved using a PSMS.<br />Conclusions: The relationship between SREs and mortality among older men with metastatic PCa was driven by SCC and depended on the definition used to measure SREs.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Bone Neoplasms mortality
Cost of Illness
Epidemiologic Methods
Fractures, Spontaneous mortality
Humans
Male
Spinal Cord Compression etiology
Spinal Cord Compression mortality
Spinal Neoplasms mortality
Spinal Neoplasms secondary
United States epidemiology
Bone Neoplasms secondary
Prostatic Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1879-4076
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of geriatric oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24726866
- Full Text :
- https://doi.org/10.1016/j.jgo.2014.03.002