Back to Search
Start Over
Interactions of cyclic and non-cyclic naphthalene diimide derivatives with different nucleic acids.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 May 01; Vol. 22 (9), pp. 2593-601. Date of Electronic Publication: 2014 Mar 28. - Publication Year :
- 2014
-
Abstract
- Recently, strategy based on stabilization of G-quadruplex telomeric DNA by small organic molecule has been realized by naphthalene diimide derivatives (NDIs). At the same time NDIs bind to DNA duplex as threading intercalators. Here we present cyclic derivative of naphthalene diimide (ligand 1) as DNA-binding ligand with ability to recognition of different structures of telomeric G-quadruplexes and ability to bis-intercalate to double-stranded helixes. The results have been compared to non-cyclic derivative (ligand 2) and revealed that preferential binding of ligands to nucleic acids strongly depends on their topology and structural features of ligands.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Circular Dichroism
DNA chemistry
Imides metabolism
Intercalating Agents chemistry
Intercalating Agents metabolism
Ligands
Naphthalenes metabolism
Oligonucleotides metabolism
Telomerase metabolism
Transition Temperature
DNA metabolism
G-Quadruplexes
Imides chemistry
Naphthalenes chemistry
Oligonucleotides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 22
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 24726302
- Full Text :
- https://doi.org/10.1016/j.bmc.2014.03.034