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Immunological alterations and associated diseases in mandrills (Mandrillus sphinx) naturally co-infected with SIV and STLV.
- Source :
-
Virology [Virology] 2014 Apr; Vol. 454-455, pp. 184-96. Date of Electronic Publication: 2014 Mar 07. - Publication Year :
- 2014
-
Abstract
- Mandrills are naturally infected with simian T-cell leukaemia virus type 1 (STLV-1) and simian immunodeficiency virus (SIV)mnd. In humans, dual infection with human immunodeficiency virus (HIV) and human T-cell lymphotropic virus type 1 (HTLV-1) may worsen their clinical outcome. We evaluated the effect of co-infection in mandrills on viral burden, changes in T-cell subsets and clinical outcome. The SIV viral load was higher in SIV-infected mandrills than in co-infected animals, whereas the STLV-1 proviral load was higher in co-infected than in mono-infected groups. Dually infected mandrills had a statistically significantly lower CD4+ T-cell count, a lower proportion of naive CD8+ T cells and a higher proportion of central memory cells. CD4(+) and CD8(+) T cells from SIV-infected animals had a lower percentage of Ki67 than those from the other groups. Co-infected monkeys had higher percentages of activated CD4(+) and CD8(+) T cells. Two co-infected mandrills with high immune activation and clonal integration of STLV provirus showed pathological manifestations (infective dermatitis and generalised scabies) rarely encountered in nonhuman primates.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Coinfection complications
Coinfection immunology
Coinfection virology
Deltaretrovirus Infections complications
Deltaretrovirus Infections immunology
Deltaretrovirus Infections virology
Mandrillus
Simian Acquired Immunodeficiency Syndrome pathology
Simian Acquired Immunodeficiency Syndrome virology
T-Lymphocyte Subsets immunology
Viral Load
Coinfection veterinary
Deltaretrovirus Infections veterinary
Simian Acquired Immunodeficiency Syndrome complications
Simian Acquired Immunodeficiency Syndrome immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0341
- Volume :
- 454-455
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 24725945
- Full Text :
- https://doi.org/10.1016/j.virol.2014.02.019