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Patterns of transmitted HIV drug resistance in Europe vary by risk group.
- Source :
-
PloS one [PLoS One] 2014 Apr 10; Vol. 9 (4), pp. e94495. Date of Electronic Publication: 2014 Apr 10 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported.<br />Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression.<br />Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (<1 year) (p<0.001). The prevalence of TDRM was highest in MSM (prevalence of 11.1%), followed by heterosexuals (6.6%) and IDU (5.1%, p<0.001). TDRM was predominantly ascribed to nucleoside reverse transcriptase inhibitors (NRTI) with a prevalence of 6.6% in MSM, 3.3% in heterosexuals and 2.0% in IDU (p = 0.001). A significant increase in resistance to non- nucleoside reverse transcriptase inhibitors (NNRTIs) and a decrease in resistance to protease inhibitors was observed in MSM (p = 0.008 and p = 0.006, respectively), but not in heterosexual patients (p = 0.68 and p = 0.14, respectively).<br />Conclusions: MSM showed to have significantly higher TDRM prevalence compared to heterosexuals and IDU. The increasing NNRTI resistance in MSM is likely to negatively influence the therapy response of first-line therapy, as most include NNRTI drugs.
- Subjects :
- Adult
Europe epidemiology
Female
HIV Infections drug therapy
HIV Infections epidemiology
HIV Infections virology
Heterosexuality statistics & numerical data
Homosexuality, Male statistics & numerical data
Humans
Logistic Models
Male
Middle Aged
Protease Inhibitors therapeutic use
Reverse Transcriptase Inhibitors therapeutic use
Risk
Sexual Behavior statistics & numerical data
Substance Abuse, Intravenous epidemiology
Anti-HIV Agents therapeutic use
Drug Resistance, Viral
HIV Infections transmission
HIV-1 drug effects
Risk-Taking
Substance Abuse, Intravenous virology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 24721998
- Full Text :
- https://doi.org/10.1371/journal.pone.0094495