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The cerebrospinal fluid "Alzheimer profile": easily said, but what does it mean?
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2014 Nov; Vol. 10 (6), pp. 713-723.e2. Date of Electronic Publication: 2014 Apr 08. - Publication Year :
- 2014
-
Abstract
- Background: We aimed to identify the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-ß1-42 (Aβ42), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimer's disease (AD).<br />Methods: We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442).<br />Results: Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/Aβ42 ratio and 0.08 for the p-tau/Aβ42 ratio. Ratios performed similar to formulas (sensitivity, 91%-93%; specificity, 81%-84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/Aβ42 ratio.<br />Conclusions: A tau/Aβ42 ratio of >0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers.<br /> (Copyright © 2014. Published by Elsevier Inc.)
- Subjects :
- Aged
Alzheimer Disease complications
Analysis of Variance
Apolipoproteins E genetics
Cognition Disorders etiology
Cohort Studies
Diagnosis, Differential
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Netherlands
Phosphorylation
ROC Curve
Regression Analysis
Alzheimer Disease cerebrospinal fluid
Alzheimer Disease diagnosis
Amyloid beta-Peptides cerebrospinal fluid
Peptide Fragments cerebrospinal fluid
tau Proteins cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 10
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 24721526
- Full Text :
- https://doi.org/10.1016/j.jalz.2013.12.023