CMTM5 exhibits tumor suppressor activity through promoter methylation in oral squamous cell carcinoma.

Authors :: Zhang H
Nan X
Li X
Chen Y
Zhang J
Sun L
Han W
Li T
Source :: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2014 May 02; Vol. 447 (2), pp. 304-10. Date of Electronic Publication: 2014 Apr 08.
Publication Year :: 2014
Abstract: Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancies in the head and neck region. CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) has been recently implicated as a tumor suppressor gene in several cancer types. Herein, we examined the expression and function of CMTM5 in oral squamous cell carcinoma. CMTM5 was down-regulated in oral squamous cell lines and tumor samples from patients with promoter methylation. Treatment with the demethylating agent 5-aza-2'-deoxycytidine restored CMTM5 expression. In the OSCC cell lines CAL27 and GNM, the ectopic expression of CMTM5-v1 strongly inhibited cell proliferation and migration and induced apoptosis. In addition, CMTM5-v1 inhibited tumor formation in vivo. Therefore, CMTM5 might act as a putative tumor suppressor gene through promoter methylation in oral squamous cell carcinoma.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)

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