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Significance of p16 expression in head and neck cancer patients treated with radiotherapy and cetuximab.
- Source :
-
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2014 Sep; Vol. 190 (9), pp. 832-8. Date of Electronic Publication: 2014 Apr 09. - Publication Year :
- 2014
-
Abstract
- Background: HPV-infection, p16 positivity, and EGFR expression have been correlated with favorable responses of head and neck cancer patients treated with radiotherapy (RT) with or without chemotherapy. However, a possible correlation of HPV/p16 and EGFR status on the effect of RT in combination with cetuximab has not been sufficiently investigated.<br />Materials and Methods: We analyzed tumor samples for p16 and EGFR expression and correlated these variables with treatment outcome. Cox-proportional-hazard regression models were applied to compare the risk of death among patients stratified according to risk factors. Survival was estimated by the Kaplan-Meier method. Results were compared with an institutional historical control group treated without cetuximab and with published data.<br />Results: Expression of p16 was predominantly found in oropharyngeal squamous cell cancer patients (OPSCC; 36.6% positivity; 92% of all cases), while EGFR was expressed at high levels in all tumor subsites (82%). p16 expression was associated with improved overall survival in irradiated OPSCC patients (2-year overall survival of 80% in p16-positive vs. 33% overall survival in p16-negative patients). In a multivariable analysis covering all tumor sites, nodal stage (> N2a vs. ≤ N2a) and tumor site (OPSSC vs. non-OPSCC) had an impact on overall survival.<br />Conclusion: Our results show that p16 positivity is associated with a favorable outcome in OPSCC patients treated with RT and cetuximab.
- Subjects :
- Aged
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell pathology
Cetuximab
Cyclin-Dependent Kinase Inhibitor p16
Disease-Free Survival
Dose Fractionation, Radiation
ErbB Receptors
Female
Gene Expression Regulation, Neoplastic drug effects
Gene Expression Regulation, Neoplastic genetics
Gene Expression Regulation, Neoplastic radiation effects
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis pathology
Male
Middle Aged
Neoplasm Staging
Otorhinolaryngologic Neoplasms genetics
Otorhinolaryngologic Neoplasms mortality
Otorhinolaryngologic Neoplasms pathology
Antibodies, Monoclonal, Humanized therapeutic use
Carcinoma, Squamous Cell therapy
Chemoradiotherapy
Neoplasm Proteins genetics
Otorhinolaryngologic Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1439-099X
- Volume :
- 190
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
- Publication Type :
- Academic Journal
- Accession number :
- 24715244
- Full Text :
- https://doi.org/10.1007/s00066-014-0652-y