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Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in Japanese: the Suita study.
- Source :
-
American journal of hypertension [Am J Hypertens] 2014 Nov; Vol. 27 (11), pp. 1362-9. Date of Electronic Publication: 2014 Apr 08. - Publication Year :
- 2014
-
Abstract
- Background: Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) and ischemic stroke. However, the hazards of their coexistence are not fully understood in Asian populations. We investigated whether the relationship between BP and cardiovascular disease (CVD) outcomes are modified by LDL-C level in a Japanese population.<br />Methods: Individuals aged 30-79 years (n = 5,151) were classified into 6 groups according to LDL-C levels (<140 and ≥140mg/dL or lipid medication) and BP levels (optimal BP, prehypertension, and hypertension; reference: low LDL-C and optimal BP). Hazard ratios (HRs) were calculated after adjusting for age, high-density lipoprotein cholesterol, diabetes, smoking status, and alcohol consumption. The effect modification of LDL-C on BP-CVD association was assessed using likelihood ratio tests.<br />Results: There were 264 CAD and 215 ischemic stroke events during 13 years of follow-up. With low LDL-C, the HRs of prehypertension and hypertension for CAD were 2.01 and 4.71, respectively. Similar trends of HRs were observed with high LDL-C (optimal BP = 2.09, prehypertension = 3.45, hypertension = 5.94). However, the HRs for ischemic stroke did not differ between normal and high LDL-C levels at the same BP level. The apparent effect modification of LDL-C was not observed in the BP-CVD association in either CAD (P = 0.48) or ischemic stroke (P = 0.39).<br />Conclusions: The HRs for CAD in prehypertensive and hypertensive groups were higher than those in the optimal BP group at the same LDL-C levels in a Japanese population; however, there was no statistical effect modification of LDL-C on the BP-CAD association.<br /> (© American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Adult
Aged
Biomarkers blood
Brain Ischemia blood
Brain Ischemia diagnosis
Brain Ischemia physiopathology
Chi-Square Distribution
Coronary Artery Disease blood
Coronary Artery Disease diagnosis
Coronary Artery Disease physiopathology
Dyslipidemias blood
Dyslipidemias diagnosis
Female
Health Surveys
Humans
Hypertension diagnosis
Hypertension physiopathology
Incidence
Japan epidemiology
Life Style ethnology
Likelihood Functions
Male
Middle Aged
Odds Ratio
Prehypertension ethnology
Prehypertension physiopathology
Proportional Hazards Models
Risk Factors
Stroke blood
Stroke diagnosis
Stroke physiopathology
Time Factors
Asian People
Blood Pressure
Brain Ischemia ethnology
Cholesterol, LDL blood
Coronary Artery Disease ethnology
Dyslipidemias ethnology
Hypertension ethnology
Stroke ethnology
Subjects
Details
- Language :
- English
- ISSN :
- 1941-7225
- Volume :
- 27
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- American journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 24713850
- Full Text :
- https://doi.org/10.1093/ajh/hpu059