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Gallbladder cancer in Chile: Pathologic characteristics of survival and prognostic factors: analysis of 1,366 cases.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2014 May; Vol. 141 (5), pp. 675-82. - Publication Year :
- 2014
-
Abstract
- Objectives: To explore gallbladder cancer (GBC), the second leading cause of cancer-related death in women in Chile.<br />Methods: Analysis of macroscopic and microscopic variables, morphometry, and survival in 1,366 patients with GBC.<br />Results: Patients comprised 1,138 women and 228 men; diagnoses included 213 (15.6%) cases of mucosal carcinoma, 132 (9.7%) cases of muscular carcinoma, 316 (23.1%) cases of subserosal carcinoma, 382 (28.0%) cases of serosal carcinoma, and 323 (23.6%) cases beyond the serosa. Women older than 55 years with a gallbladder length greater than 9.5 cm had a five-times-greater relative risk of cancer. Those with a gallbladder wall thickness less than 7 mm had a better 5-year survival rate than those with a gallbladder wall thickness greater than 10 mm (P = .0001). Patients who had cholesterolosis of the gallbladder had 9.2 times less probability of having cancer. The infiltration level of the gallbladder wall was the most important independent prognostic factor (P < .001), followed by differentiation and lymphatic involvement (P < .001 and P = .05, respectively). Vascular infiltration had a mortality rate of 100%.<br />Conclusions: Morphologic features are strongly associated with the prognosis of GBC and must be taken into consideration when supplementary treatment is recommended.
Details
- Language :
- English
- ISSN :
- 1943-7722
- Volume :
- 141
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 24713738
- Full Text :
- https://doi.org/10.1309/AJCPQT3ELN2BBCKA