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Long-term testosterone treatment in elderly men with hypogonadism and erectile dysfunction reduces obesity parameters and improves metabolic syndrome and health-related quality of life.
- Source :
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The journal of sexual medicine [J Sex Med] 2014 Jun; Vol. 11 (6), pp. 1567-76. Date of Electronic Publication: 2014 Apr 08. - Publication Year :
- 2014
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Abstract
- Introduction: Late-onset hypogonadism (LOH) is diagnosed when declining testosterone concentrations in the aging male cause unwanted symptoms such as erectile dysfunction (ED), reduced bone density and muscle strength, and increased visceral obesity. Testosterone deficiency is also associated with insulin resistance and the metabolic syndrome (MetS). Restoring testosterone to physiological concentrations has beneficial effects on many of these symptoms; however, it is not known whether these effects can be sustained in the long term.<br />Aims: To investigate whether treatment with testosterone undecanoate (TU) has a long-term and sustained effect on parameters affected by the MetS in men with LOH and ED, to determine whether long-term testosterone treatment can improve the overall health-related quality of life in these men, and to establish the safety of long-term testosterone treatment.<br />Methods: Two hundred sixty-one patients (mean age 59.5â±â8.4 years) diagnosed with LOH and ED were treated with long-acting TU in a prospective, observational, and longitudinal registry study. Men received intramuscular injections of 1,000âmg TU at day 1, at week 6, and every 3 months thereafter.<br />Main Outcome Measures: Parameters affected by the MetS, including obesity parameters (body weight, waist circumference, and body mass index [BMI]), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, glucose, HbA1c (glycated hemoglobin), and blood pressure, as well as total testosterone levels and health-related quality of life, were assessed.<br />Results: We found TU significantly improved obesity parameters (body weight, waist circumference, and BMI) and lowered total cholesterol, LDL cholesterol, triglycerides, fasting blood glucose, HbA1c , and blood pressure over the 5-year study. HDL cholesterol was increased. TU treatment resulted in a sustained improvement in erectile function and muscle and joint pain, which contributed to an improvement in long-term health-related quality of life. Furthermore, we found a relationship between health-related quality of life and waist circumference. Finally, we found no evidence that long-term treatment with TU increases the risk of prostate carcinoma.<br />Conclusion: Long-term TU in men with LOH and ED reduces obesity parameters and improves metabolic syndrome and health-related quality of life.<br /> (© 2014 International Society for Sexual Medicine.)
- Subjects :
- Aged
Body Composition
Body Mass Index
Body Weight
Cholesterol, HDL blood
Cholesterol, LDL metabolism
Humans
Male
Metabolic Syndrome drug therapy
Middle Aged
Penile Erection drug effects
Prospective Studies
Quality of Life
Testosterone therapeutic use
Triglycerides metabolism
Waist Circumference
Androgens therapeutic use
Erectile Dysfunction drug therapy
Hypogonadism drug therapy
Obesity drug therapy
Testosterone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1743-6109
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The journal of sexual medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24712761
- Full Text :
- https://doi.org/10.1111/jsm.12523