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Prognostic value of c-FLIPL/s, HIF-1α, and NF-κβ in stage II and III rectal cancer.
- Source :
-
Virchows Archiv : an international journal of pathology [Virchows Arch] 2014 Jun; Vol. 464 (6), pp. 645-54. Date of Electronic Publication: 2014 Apr 08. - Publication Year :
- 2014
-
Abstract
- Locally advanced rectal cancer (LARC) is associated with a 25 % rate of metastases. The prognostic and predictive relevances of the expression of five proteins (c-FLIPL/s, HIF-1α, β-catenin, p65, and p105/p50 NF-κβ) were assessed. This is a retrospective study. From 1998 to 2009, 152 patients with stage II/III rectal cancer were treated with radio-chemotherapy. TMAs constructed with tumor and normal tissue from the diagnostic endoscopic biopsy and the surgical specimen after chemoradiotherapy were subjected to immunohistochemical (IHC) analysis. Results were correlated with clinical and pathological data, including progression-free survival (PFS). Four different IHC conditions were independent prognostic parameters for PFS: (1) cytoplasmic c-FLIPL/s (p = 0.007), (2) nuclear HIF-1α (p = 0.020), (3) a change in the cytoplasmic p65 between the diagnostic biopsy and the post-treatment specimen (p = 0.004), and (4) a change in the cytoplasmic c-FLIPL/s between the diagnostic biopsy and the post-treatment specimen (p = 0.021). Three different protein expression profiles, combining biomarkers, showed prognostic significance. IHC evaluation of these biomarkers in our three protein expression profiles may help to identify patients with worse prognosis and design more effective therapeutic strategies to personalize the treatment of rectal cancer.
- Subjects :
- Aged
CASP8 and FADD-Like Apoptosis Regulating Protein analysis
Disease-Free Survival
Female
Humans
Hypoxia-Inducible Factor 1, alpha Subunit analysis
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
NF-kappa B analysis
Neoplasm Staging
Prognosis
Proportional Hazards Models
Rectal Neoplasms metabolism
Rectal Neoplasms mortality
Retrospective Studies
Tissue Array Analysis
Biomarkers, Tumor analysis
CASP8 and FADD-Like Apoptosis Regulating Protein biosynthesis
Hypoxia-Inducible Factor 1, alpha Subunit biosynthesis
NF-kappa B biosynthesis
Rectal Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2307
- Volume :
- 464
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Virchows Archiv : an international journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 24711168
- Full Text :
- https://doi.org/10.1007/s00428-014-1572-z