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Sarcopenia is linked to treatment toxicity in patients with metastatic colorectal cancer.
- Source :
-
Nutrition and cancer [Nutr Cancer] 2014; Vol. 66 (4), pp. 583-9. Date of Electronic Publication: 2014 Apr 07. - Publication Year :
- 2014
-
Abstract
- Chemotherapy toxicity could be linked to decreased skeletal muscle (sarcopenia). We evaluated the effect of sarcopenia on chemotherapy toxicity among metastatic colorectal cancer (mCRC) patients. All consecutive mCRC patients in 3 hospitals were enrolled in this prospective, cross-sectional, multicenter study. Several nutritional indexes and scores were generated. Computed tomography (CT) images were analyzed to evaluate cross-sectional areas of muscle tissue (MT), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Toxicities were evaluated in the 2 mo following clinical evaluation. Fifty-one mCRC patients were included in the study. Sarcopenia was observed in 71% of patients (39% of women and 82% of men) whereas only 4% and 18% were considered as underweight using body mass index (BMI) or severely malnourished using the Nutritional Risk Index (NRI), respectively. Grade 3-4 toxicities were observed in 28% of patients. In multivariate analysis including age, sex, BMI, sarcopenia, SAT, and VAT, the only factor associated with Grade 3-4 toxicities was sarcopenia (odds ratio = 13.55; 95% confidence interval [1.08; 169.31], P = 0.043). In mCRC patients undergoing chemotherapy, sarcopenia was much more frequently observed than visible malnutrition. Despite the small number of patients included in our study, we found sarcopenia to be significantly associated with severe chemotherapy toxicity.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal, Humanized administration & dosage
Antineoplastic Agents administration & dosage
Body Composition drug effects
Body Mass Index
Camptothecin administration & dosage
Camptothecin adverse effects
Cetuximab
Cross-Sectional Studies
Female
Humans
Intra-Abdominal Fat drug effects
Intra-Abdominal Fat pathology
Irinotecan
Male
Middle Aged
Muscle, Skeletal drug effects
Muscle, Skeletal pathology
Neoplasm Metastasis
Nutrition Assessment
Prospective Studies
Sarcopenia chemically induced
Young Adult
Antibodies, Monoclonal, Humanized adverse effects
Antineoplastic Agents adverse effects
Antineoplastic Agents toxicity
Camptothecin analogs & derivatives
Colorectal Neoplasms drug therapy
Sarcopenia pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-7914
- Volume :
- 66
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nutrition and cancer
- Publication Type :
- Academic Journal
- Accession number :
- 24707897
- Full Text :
- https://doi.org/10.1080/01635581.2014.894103