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Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2014 Oct; Vol. 211 (4), pp. 385.e1-9. Date of Electronic Publication: 2014 Apr 03. - Publication Year :
- 2014
-
Abstract
- Objective: The objective of the study was to determine the diagnostic indices and predictive values by bedside assessment of amniotic fluid interleukin-6 (IL-6) concentration in the identification of microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA) in patients with preterm prelabor rupture of membranes.<br />Study Design: One hundred twenty-four women with singleton pregnancies were included in this study. The amniotic fluid was sampled by transabdominal amniocentesis at the time of admission. IL-6 concentrations were assessed with an immunoassay.<br />Results: The presence of MIAC, HCA, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6 in both a crude and adjusted analysis. The amniotic fluid concentration of IL-6 of 1000 pg/mL was determined to be the best cutoff value for the prediction of MIAC (sensitivity of 50%, specificity of 95%, positive predictive value of 82%, negative predictive value of 81%, and likelihood ratio of 8.4) or both MIAC and HCA (sensitivity of 60%, specificity of 94%, positive predictive value of 75%, negative predictive value of 88%, and likelihood ratio of 9.4).<br />Conclusion: The bedside assessment of amniotic fluid IL-6 seems to be an easy, rapid, and inexpensive method for the prediction of MIAC or both MIAC and HCA in pregnancies complicated by preterm prelabor rupture of membranes.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Amniotic Fluid microbiology
Biomarkers metabolism
Chlamydia Infections diagnosis
Chlamydia trachomatis isolation & purification
Chorioamnionitis metabolism
Female
Fetal Membranes, Premature Rupture metabolism
Humans
Mycoplasma hominis isolation & purification
Predictive Value of Tests
Pregnancy
Pregnancy Complications, Infectious metabolism
Prospective Studies
Sensitivity and Specificity
Ureaplasma Infections diagnosis
Ureaplasma Infections metabolism
Young Adult
Amniocentesis
Amniotic Fluid metabolism
Chorioamnionitis diagnosis
Interleukin-6 metabolism
Mycoplasma Infections diagnosis
Point-of-Care Systems
Pregnancy Complications, Infectious diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 211
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 24705131
- Full Text :
- https://doi.org/10.1016/j.ajog.2014.03.069