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Properties of gramicidin A channels in erythrocyte membranes.
- Source :
-
Biochimie [Biochimie] 1989 Jan; Vol. 71 (1), pp. 99-104. - Publication Year :
- 1989
-
Abstract
- Studies for the cation permeability properties of the gramicidin A channel in erythrocyte membranes are presented. It is shown that gramicidin A interacts with the membrane in a cooperative manner, creating aggregates of the antibiotic molecules in the lipid lattice of the membrane. Cationic channels exist in these aggregates with the following order of selectivity: Rb+ greater than Cs+ greater K+ greater than Na+. The cation permeability of the channels depends on the media surrounding the membrane. This finding has been explained on the basis of Hodgkin-Keynes theory for single-file ion diffusion through extra-narrow pores.
Details
- Language :
- English
- ISSN :
- 0300-9084
- Volume :
- 71
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochimie
- Publication Type :
- Academic Journal
- Accession number :
- 2470422
- Full Text :
- https://doi.org/10.1016/0300-9084(89)90138-7