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New advances in CMV and immunosenescence.

Authors :: Sansoni P
Vescovini R
Fagnoni FF
Akbar A
Arens R
Chiu YL
Cičin-Šain L
Dechanet-Merville J
Derhovanessian E
Ferrando-Martinez S
Franceschi C
Frasca D
Fulöp T
Furman D
Gkrania-Klotsas E
Goodrum F
Grubeck-Loebenstein B
Hurme M
Kern F
Lilleri D
López-Botet M
Maier AB
Marandu T
Marchant A
Matheï C
Moss P
Muntasell A
Remmerswaal EB
Riddell NE
Rothe K
Sauce D
Shin EC
Simanek AM
Smithey MJ
Söderberg-Nauclér C
Solana R
Thomas PG
van Lier R
Pawelec G
Nikolich-Zugich J
Source :: Experimental gerontology [Exp Gerontol] 2014 Jul; Vol. 55, pp. 54-62. Date of Electronic Publication: 2014 Apr 03.
Publication Year :: 2014
Abstract: Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.<br /> (Copyright © 2014. Published by Elsevier Inc.)