Interleukin-28B polymorphisms and response of chronic hepatitis C patients from Indonesia to pegylated interferon/ribavirin treatment.

Authors :: Juniastuti
Wibowo BP
Wibawa ID
Utsumi T
Mustika S
Amin M
Wahyuni RM
Kurniawan H
Hendrayana A
Setiawan PB
Yamani LN
Soetjipto
Yano Y
Hotta H
Hayashi Y
Lusida MI
Source :: Journal of clinical microbiology [J Clin Microbiol] 2014 Jun; Vol. 52 (6), pp. 2193-5. Date of Electronic Publication: 2014 Apr 02.
Publication Year :: 2014
Abstract: This study demonstrated that Indonesian patients with chronic hepatitis C (mostly ethnic Java people) mostly were infected with hepatitis C virus (HCV) genotype 1; however, they carried mainly the major genotypes of interleukin 28B (IL-28B) single nucleotide polymorphisms (SNPs) (rs12979860 CC, rs11881222 TT, rs8103142 AA, and rs8099917 TT), and they mostly achieved sustained virological responses to pegylated interferon/ribavirin treatment.<br /> (Copyright © 2014, American Society for Microbiology. All Rights Reserved.)

Subjects :: Adult
Aged
Female
Gene Frequency
Genotype
Humans
Indonesia
Interferons
Male
Middle Aged
Polymorphism, Single Nucleotide
Treatment Outcome
Hepatitis C, Chronic drug therapy
Interferon-alpha therapeutic use
Interleukins genetics
Ribavirin therapeutic use

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