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Implications of differential age distribution of disease-associated meningococcal lineages for vaccine development.
- Source :
-
Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2014 Jun; Vol. 21 (6), pp. 847-53. Date of Electronic Publication: 2014 Apr 02. - Publication Year :
- 2014
-
Abstract
- New vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A collection of 4,048 representative meningococcal disease isolates from 18 European countries, collected over a 3-year period, were characterized by multilocus sequence typing (MLST). Age data were available for 3,147 isolates. The proportions of hyperinvasive lineages, identified as particular clonal complexes (ccs) by MLST, differed among age groups. Subjects <1 year of age experienced lower risk of sequence type 11 (ST-11) cc, ST-32 cc, and ST-269 cc disease and higher risk of disease due to unassigned STs, 1- to 4-year-olds experienced lower risk of ST-11 cc and ST-32 cc disease, 5- to 14-year-olds were less likely to experience ST-11 cc and ST-269 cc disease, and ≥25-year-olds were more likely to experience disease due to less common ccs and unassigned STs. Younger and older subjects were vulnerable to a more diverse set of genotypes, indicating the more clonal nature of genotypes affecting adolescents and young adults. Knowledge of temporal and spatial diversity and the dynamics of meningococcal populations is essential for disease control by vaccines, as coverage is lineage specific. The nonrandom age distribution of hyperinvasive lineages has consequences for the design and implementation of vaccines, as different variants, or perhaps targets, may be required for different age groups.<br /> (Copyright © 2014 Brehony et al.)
- Subjects :
- Adolescent
Adult
Age Distribution
Antigens, Bacterial immunology
Base Sequence
Child
Child, Preschool
Humans
Infant
Meningitis, Meningococcal immunology
Meningitis, Meningococcal microbiology
Multilocus Sequence Typing
Neisseria meningitidis isolation & purification
Sequence Analysis, DNA
Young Adult
Bacterial Capsules immunology
Meningitis, Meningococcal prevention & control
Meningococcal Vaccines immunology
Neisseria meningitidis immunology
Neisseria meningitidis, Serogroup B immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1556-679X
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical and vaccine immunology : CVI
- Publication Type :
- Academic Journal
- Accession number :
- 24695776
- Full Text :
- https://doi.org/10.1128/CVI.00133-14