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Persistence of the natriuretic effect of calcium entry blockers.
- Source :
-
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 1988; Vol. 12 Suppl 4, pp. S136-9. - Publication Year :
- 1988
-
Abstract
- In order to elucidate whether or not the natriuretic properties of calcium entry blockers persist during the long-term administration of the drug, we have investigated the renal capacity to excrete an intravenous sodium load (2,000 ml of isotonic saline in 4 h) in a group of eight mild to moderate essential hypertensive patients, before and after 1, 8, and 24 weeks of treatment with nitrendipine. The following parameters were measured before and hourly during saline infusion: blood pressure, and plasma and urine sodium and potassium. For 5 days prior to the performance of the test, the patients received a diet containing 120 mEq of sodium daily. Nitrendipine induced a significant fall of both systolic and diastolic blood pressure (p less than 0.05-0.01) that was maintained throughout the study. A significant increase of the cumulative renal sodium output (microEq/min/h) was observed after 1, 8, and 24 weeks (p less than 0.05-0.001) of therapy with the calcium entry blocker. Meanwhile, plasma sodium and potassium and the kaliuresis did not change significantly. These results indicate that the natriuretic effect of calcium entry blockers is still present after long-term treatment.
- Subjects :
- Adult
Blood Pressure drug effects
Calcium Channel Blockers therapeutic use
Creatinine blood
Humans
Hypertension drug therapy
Hypertension urine
Male
Middle Aged
Nitrendipine therapeutic use
Potassium urine
Sodium urine
Calcium Channel Blockers pharmacology
Natriuresis drug effects
Nitrendipine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0160-2446
- Volume :
- 12 Suppl 4
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2468857
- Full Text :
- https://doi.org/10.1097/00005344-198806124-00030