Back to Search
Start Over
Long-term cardiovascular consequences of Rose angina at age 20-54 years: 29-years' follow-up of the Tromsø Study.
- Source :
-
Journal of epidemiology and community health [J Epidemiol Community Health] 2014 Aug; Vol. 68 (8), pp. 754-9. Date of Electronic Publication: 2014 Mar 31. - Publication Year :
- 2014
-
Abstract
- Background: The Rose Angina Questionnaire (RAQ) was constructed in the 1960s for assessing the population burden of angina. Studies have found that screening positivity by RAQ conferred an elevated risk of coronary heart disease (CHD). It is, however, not clear to what extent Rose angina represents early CHD in relatively young adults who are free of known CHD. If representing CHD, Rose angina is expected to carry prognostic information in addition to the risk conferred by other risk factors.<br />Methods: The Tromsø Study is a population-based cohort study in Northern Norway. All men aged 20-54 years (n=8238) and women aged 20-49 years (n=8001), free of known cardiovascular disease (CVD), who participated in a survey 1979-1980, were followed throughout 2010 for incident myocardial infarction (MI), and for incident MI or stroke used as proxy for incident CVD. HRs were estimated using a Cox proportional hazard regression model.<br />Results: In age-adjusted analyses, Rose angina predicted MI and CVD in both sexes. The excess risk was substantially accounted for by CVD risk factors, leaving no significantly elevated MI risk above the risk explained by these factors (adjusted HR 1.31; 95% CI 0.95 to 1.80 in men, HR 1.20; 95% CI 0.69 to 2.10 in women). A similar pattern was seen for CVD (adjusted HR 1.16; 95% CI 0.87 to 1.55 in men and 1.30; 95% CI 0.82 to 2.06 in women).<br />Conclusions: Rose angina predicted MI and CVD in a 29-years' follow-up of a relatively young population. Established CVD risk factors were important mediators.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
- Subjects :
- Adult
Aged
Cardiovascular Diseases mortality
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction epidemiology
Norway epidemiology
Predictive Value of Tests
Proportional Hazards Models
Risk Assessment
Surveys and Questionnaires
Young Adult
Angina Pectoris
Cardiovascular Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1470-2738
- Volume :
- 68
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of epidemiology and community health
- Publication Type :
- Academic Journal
- Accession number :
- 24687910
- Full Text :
- https://doi.org/10.1136/jech-2013-203642