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Hypoiodite-mediated cyclopropanation of alkenes.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2014 May 12; Vol. 20 (20), pp. 5895-8. Date of Electronic Publication: 2014 Mar 28. - Publication Year :
- 2014
-
Abstract
- An efficient, transition metal-free procedure for the cyclopropanation of alkenes using malononitrile and the LiI-tBuOCl combination under mild reaction conditions is described. The reaction mechanism most likely involves tBuOI generated in situ from LiI and tBuOCl. The utility of this new methodology has been demonstrated by the synthesis of a potential HIV-1 RT inhibitor.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Alkenes chemical synthesis
Anti-HIV Agents chemical synthesis
Anti-HIV Agents chemistry
Cyclization
Cyclopropanes chemical synthesis
Iodine chemistry
Iodine Compounds chemical synthesis
Oxidation-Reduction
Reverse Transcriptase Inhibitors chemical synthesis
Reverse Transcriptase Inhibitors chemistry
Alkenes chemistry
Cyclopropanes chemistry
Iodine Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 20
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 24687271
- Full Text :
- https://doi.org/10.1002/chem.201402372