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Association between postmenopausal osteoporosis and experimental periodontitis.
- Source :
-
BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 316134. Date of Electronic Publication: 2014 Feb 10. - Publication Year :
- 2014
-
Abstract
- To investigate the correlation between postmenopausal osteoporosis (PMO) and the pathogenesis of periodontitis, ovariectomized rats were generated and the experimental periodontitis was induced using a silk ligature. The inflammatory factors and bone metabolic markers were measured in the serum and periodontal tissues of ovariectomized rats using an automatic chemistry analyzer, enzyme-linked immunosorbent assays, and immunohistochemistry. The bone mineral density of whole body, pelvis, and spine was analyzed using dual-energy X-ray absorptiometry and image analysis. All data were analyzed using SPSS 13.0 statistical software. It was found that ovariectomy could upregulate the expression of interleukin- (IL-)6, the receptor activator of nuclear factor- κB ligand (RANKL), and osteoprotegerin (OPG) and downregulate IL-10 expression in periodontal tissues, which resulted in progressive alveolar bone loss in experimental periodontitis. This study indicates that changes of cytokines and bone turnover markers in the periodontal tissues of ovariectomized rats contribute to the damage of periodontal tissues.
- Subjects :
- Alveolar Bone Loss blood
Alveolar Bone Loss complications
Alveolar Bone Loss pathology
Alveolar Bone Loss physiopathology
Animals
Bone Density
Cell Count
Cytokines blood
Female
Humans
Immunohistochemistry
Molar pathology
Osteoporosis, Postmenopausal blood
Osteoporosis, Postmenopausal pathology
Osteoporosis, Postmenopausal physiopathology
Pelvis pathology
Pelvis physiopathology
Periodontal Ligament pathology
Periodontitis blood
Periodontitis pathology
Periodontitis physiopathology
Rats, Sprague-Dawley
Spine pathology
Spine physiopathology
Osteoporosis, Postmenopausal complications
Periodontitis complications
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2014
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 24683547
- Full Text :
- https://doi.org/10.1155/2014/316134