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First use of (18)F-labeled ML-10 PET to assess apoptosis change in a newly diagnosed glioblastoma multiforme patient before and early after therapy.
- Source :
-
Brain and behavior [Brain Behav] 2014 Mar; Vol. 4 (2), pp. 312-5. Date of Electronic Publication: 2014 Feb 12. - Publication Year :
- 2014
-
Abstract
- Objectives: The authors present the first use of the novel positron emission tomography (PET) apoptosis tracer (18)F-labeled 2-(5-fluoro-pentyl)-2-methyl-malonic acid ((18)F-ML-10) for early-therapy response assessment of a newly diagnosed glioblastoma multiforme (GBM) patient.<br />Case Report: A 71-year-old male with a newly diagnosed GBM received (18)F-ML-10 PET scans prior to therapy initiation (baseline) and after completing 3 weeks of whole-brain radiation therapy with concomitant temozolomide chemotherapy (early-therapy assessment, ETA). The baseline (18)F-ML-10 PET scan showed increased tracer uptake at the site of the GBM, with highest activity toward the central portion of the tumor. At the ETA time point, a new distribution of tracer uptake was observed compared to baseline. Normalized pixel-by-pixel subtraction of baseline from ETA was used to quantify change in tracer distribution between (18)F-ML-10 PET imaging time points. Results of this analysis showed reduction in (18)F-ML-10 uptake at the site of greatest baseline uptake, but increased uptake around the periphery of the tumor at the early-therapy time point.<br />Conclusion: The changing patterns of (18)F-ML-10 uptake between baseline and ETA are suggestive for therapy-induced tumor cellular apoptosis.
- Subjects :
- Aged
Antineoplastic Agents, Alkylating pharmacology
Dacarbazine analogs & derivatives
Dacarbazine pharmacology
Humans
Male
Temozolomide
Treatment Outcome
Apoptosis drug effects
Apoptosis radiation effects
Brain Neoplasms diagnostic imaging
Brain Neoplasms drug therapy
Brain Neoplasms radiotherapy
Glioblastoma diagnostic imaging
Glioblastoma drug therapy
Glioblastoma radiotherapy
Methylmalonic Acid analogs & derivatives
Positron-Emission Tomography methods
Subjects
Details
- Language :
- English
- ISSN :
- 2162-3279
- Volume :
- 4
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 24683522
- Full Text :
- https://doi.org/10.1002/brb3.217