Preparation and evaluation of three mucoadhesive dosage forms using (99m)Tc-Ofloxacin.

Authors :: Mukherjee A
Sahoo S
Sarma HD
Chakraborti CK
Samuel G
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2014 Jul; Vol. 89, pp. 192-8. Date of Electronic Publication: 2014 Feb 20.
Publication Year :: 2014
Abstract: Preparation of three mucoadhesive formulations was optimized and pharmaceutically evaluated. Ofloxacin was radiolabeled with (99m)Tc and radiolabeled complex was characterized by HPLC. (99m)Tc-Ofloxacin was added as a tracer to the formulations namely Oflox C934, Oflox C940 and Oflox HPMC and the formulations were fed orally to rats. Imaging studies were carried out to assess the prolonged gastric retention of the formulations. (99m)Tc-Ofloxacin served as a good tracer for studying the pharmacokinetics of three controlled release mucoadhesive dosage forms by gamma scintigraphy studies.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Language :: English
ISSN :: 1872-9800
Volume :: 89
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 24681624
Full Text :: https://doi.org/10.1016/j.apradiso.2014.01.031

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