N-Bridged 1-deoxynojirimycin dimers as selective insect trehalase inhibitors.

Authors :: Cipolla L
Sgambato A
Forcella M
Fusi P
Parenti P
Cardona F
Bini D
Source :: Carbohydrate research [Carbohydr Res] 2014 May 07; Vol. 389, pp. 46-9. Date of Electronic Publication: 2014 Jan 30.
Publication Year :: 2014
Abstract: A small set of N-bridged 1-deoxynojirimycin dimers has been synthesized and evaluated as potential inhibitors of insect trehalase from midge larvae of Chironomus riparius, porcine trehalase as the mammalian counterpart and α-amylase from human saliva. All the tested compounds (2-4) proved to be active (micromolar range activity) against insect trehalase, showing selectivity toward the insect glycosidase. No activity was observed against α-amylase.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)