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Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes.
- Source :
-
Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2014 Jul; Vol. 7 (5), pp. 507-17. Date of Electronic Publication: 2014 Mar 28. - Publication Year :
- 2014
-
Abstract
- Correlation of the thickness of the left ventricular posterior wall (LVPWd) with various parameters, including age, gender, weight and height, was investigated in this study using regression models. Multicenter derived database comprised over 4,000 healthy individuals. The developed models were further utilized in the in vitro-in vivo (IVIV) translation of the drug cardiac safety data with use of the mathematical model of human cardiomyocytes operating at the virtual healthy population level. LVPWd was assumed to be equivalent to the length of one-dimensional string of virtual cardiomyocyte cells which was presented, as other physiological factors, to be a parameter influencing the simulated pseudo-ECG (pseudoelectrocardiogram), QTcF and ∆QTcF, both native and modified by exemplar drug (disopyramide) after I Kr current disruption. Simulation results support positive correlation between the LVPWd and QTcF/∆QTc. Developed models allow more detailed description of the virtual population and thus inter-individual variability influence on the drug cardiac safety.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Body Surface Area
Databases, Factual
Electrocardiography
Female
Healthy Volunteers
Heart drug effects
Heart Conduction System drug effects
Heart Conduction System physiology
Heart Ventricles cytology
Humans
Male
Middle Aged
Myocytes, Cardiac drug effects
Poland
Retrospective Studies
Sex Factors
Switzerland
Young Adult
Computer Simulation
Diastole drug effects
Heart physiology
Models, Cardiovascular
Myocytes, Cardiac physiology
Ventricular Function, Left drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1937-5395
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular translational research
- Publication Type :
- Academic Journal
- Accession number :
- 24676501
- Full Text :
- https://doi.org/10.1007/s12265-014-9558-4