Back to Search
Start Over
Co-delivery of doxorubicin and SATB1 shRNA by thermosensitive magnetic cationic liposomes for gastric cancer therapy.
- Source :
-
PloS one [PLoS One] 2014 Mar 27; Vol. 9 (3), pp. e92924. Date of Electronic Publication: 2014 Mar 27 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- In previous a study, we had developed a novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this system for the co-delivery of both drugs and genes to the same cell and its anti-tumor effects on gastric cancer. Doxorubicin (DOX) and SATB1 shRNA vector were loaded into the co-delivery system, and in vitro DOX thermosensitive release activity, targeted gene silencing efficiency, targeted cellular uptake, in vitro cytotoxicity, as well as in vivo anti-tumor activity were determined. The results showed that this co-delivery system had desirable targeted delivery efficacy, DOX thermosensitive release and SATB1 gene silencing. Moreover, the co-delivery of DOX and SATB1 shRNA exhibited enhanced activity to inhibit gastric cancer cell growth in vitro and in vivo, compared to single delivery. In conclusion, the novel thermosensitive magnetic drug and gene co-delivery system has promising application in combined chemotherapy and gene therapy for gastric cancer.
- Subjects :
- Animals
Cell Line, Tumor
Disease Models, Animal
Drug Liberation
Gene Silencing
Gene Transfer Techniques
Humans
Male
Particle Size
Stomach Neoplasms pathology
Stomach Neoplasms therapy
Thermodynamics
Transfection
Tumor Burden drug effects
Tumor Burden genetics
Xenograft Model Antitumor Assays
Doxorubicin administration & dosage
Drug Delivery Systems
Liposomes chemistry
Matrix Attachment Region Binding Proteins genetics
RNA, Small Interfering administration & dosage
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 24675979
- Full Text :
- https://doi.org/10.1371/journal.pone.0092924