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Real-time in vivo quantitative monitoring of drug release by dual-mode magnetic resonance and upconverted luminescence imaging.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Apr 25; Vol. 53 (18), pp. 4551-5. Date of Electronic Publication: 2014 Mar 25. - Publication Year :
- 2014
-
Abstract
- Insufficient or excess drug doses, due to unknown actual drug concentrations at the focus, are one of the main causes of chemotherapy failure for cancers. In this regard, the real-time monitoring of the release of anticancer drugs from nanoparticle drug delivery systems is of crucial importance, but it remains a critical and unsolved challenge. Herein, we report the proposal and development of a novel concept of real-time monitoring of NIR-triggered drug release in vitro and in vivo by using simultaneous upconverted luminescence (UCL) and magnetic resonance (MR) imaging. Such a monitoring strategy features the high sensitivity of UCL and the high-resolution, noninvasiveness, and tissue-depth-independence of MR imaging. The dual-mode real-time and quantitative monitoring of drug release can be applied to determine online the drug concentrations in vivo in the tissue regions of interest and, therefore, to avoid insufficient or excess drug dosings.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Antibiotics, Antineoplastic pharmacokinetics
Antibiotics, Antineoplastic pharmacology
Doxorubicin pharmacology
Gadolinium chemistry
HeLa Cells
Humans
Nanocomposites chemistry
Nanoparticles chemistry
Tissue Distribution
Cell Survival drug effects
Doxorubicin pharmacokinetics
Drug Delivery Systems
Drug Liberation
Luminescent Measurements methods
Magnetic Resonance Spectroscopy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 53
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 24668766
- Full Text :
- https://doi.org/10.1002/anie.201400900