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Tremella Polysaccharides attenuated sepsis through inhibiting abnormal CD4⁺CD25(high) regulatory T cells in mice.
- Source :
-
Cellular immunology [Cell Immunol] 2014 Mar-Apr; Vol. 288 (1-2), pp. 60-5. Date of Electronic Publication: 2014 Feb 26. - Publication Year :
- 2014
-
Abstract
- Tremella Polysaccharides (TPS) have been reported to play an important role in regulating immune responses. Tregs are widely identified as the critical reason for immune dysfunction during sepsis. However, whether TPS could influence the immunomodulatory activities of Tregs in post-burn sepsis mice remains unclear. In this experiment, we researched the effects of TPS on peripheral blood Tregs in sepsis mouse induced by burn plus Pseudomonas aeruginosa infection. Results showed that TPS reversed the influences of Tregs on CD4⁺T cells proliferation and polarization and declined the level of IL-10 in burn plus P. aeruginosa infection mice. In addition, TPS notably reduced the mortality of post-burn sepsis mice. Therefore, TPS could inhibit the abnormal activities of CD4⁺CD25(high) Tregs in burn with P. aeruginosa infection mice, at least in part via inhibiting IL-10 secretion, and trigger a shift of Th2 to Th1 with activation of CD4⁺T cells in burn with P. aeruginosa infection mice.<br /> (Copyright © 2014. Published by Elsevier Inc.)
- Subjects :
- Animals
Basidiomycota chemistry
Burns immunology
Burns microbiology
Burns pathology
CD4 Antigens genetics
CD4 Antigens immunology
Cell Proliferation drug effects
Fungal Polysaccharides isolation & purification
Gene Expression
Immunologic Factors isolation & purification
Interleukin-10 antagonists & inhibitors
Interleukin-10 genetics
Interleukin-10 immunology
Interleukin-2 Receptor alpha Subunit genetics
Interleukin-2 Receptor alpha Subunit immunology
Lymphocyte Activation drug effects
Male
Mice
Mice, Inbred BALB C
Pseudomonas Infections immunology
Pseudomonas Infections microbiology
Pseudomonas Infections pathology
Pseudomonas aeruginosa drug effects
Pseudomonas aeruginosa growth & development
Sepsis immunology
Sepsis microbiology
Sepsis pathology
T-Lymphocytes, Regulatory immunology
T-Lymphocytes, Regulatory pathology
Th1-Th2 Balance
Burns drug therapy
Fungal Polysaccharides pharmacology
Immunologic Factors pharmacology
Pseudomonas Infections drug therapy
Sepsis drug therapy
T-Lymphocytes, Regulatory drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2163
- Volume :
- 288
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Cellular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 24662726
- Full Text :
- https://doi.org/10.1016/j.cellimm.2014.02.002