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Supra-amphiphilic aggregates formed by p-sulfonatocalix[4]arenes and the antipsychotic drug chlorpromazine.
- Source :
-
Soft matter [Soft Matter] 2014 Apr 07; Vol. 10 (13), pp. 2253-63. - Publication Year :
- 2014
-
Abstract
- We report here a supramolecular strategy to directly assemble the small molecular antipsychotic drug chlorpromazine (CPZ) into nanostructures, induced by p-sulfonatocalix[4]arene (SC4A) and p-sulfonatocalix[4]arene tetraheptyl ether (SC4AH), with high drug loading efficiencies of 61% and 46%, respectively. The binary host-guest assembly process was monitored using optical transmittance measurements, and the size and morphology of these two kinds of supra-amphiphilic assemblies were identified using a combination of light scattering and high-resolution transmission electron microscopy, which showed solid spherical micelles. This strategy presents new opportunities for the development of high loading drug-containing carriers with easy processability for drug delivery.
- Subjects :
- Calixarenes chemical synthesis
Drug Carriers chemistry
Hydrogen-Ion Concentration
Micelles
Nanostructures chemistry
Nanostructures ultrastructure
Phenols chemical synthesis
Temperature
Water chemistry
Antipsychotic Agents chemistry
Calixarenes chemistry
Chlorpromazine chemistry
Phenols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1744-6848
- Volume :
- 10
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Soft matter
- Publication Type :
- Academic Journal
- Accession number :
- 24652226
- Full Text :
- https://doi.org/10.1039/c3sm52866a