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Regulators of prostate cancer stem cells.

Regulators of prostate cancer stem cells.

Authors :
Kerr CL
Hussain A
Source :
Current opinion in oncology [Curr Opin Oncol] 2014 May; Vol. 26 (3), pp. 328-33.
Publication Year :
2014

Abstract

Purpose of Review: Significant advances have been made toward identifying prostate cancer stem cells (CSCs). This review will highlight the latest developments in defining this population and the discovery of mechanisms involved in their survival and metastasis.<br />Recent Findings: Several groups have identified master regulators of stem cells in prostate cancer. These include genetic and epigenetic factors known to control pluripotency in embryonic stem cells and in highly metastatic prostate tumors. For instance, tumors of patients with poor prognosis demonstrate elevated levels of the pluripotent markers OCT4 and SOX2 as well as the polycomb complex protein Bmi-1 and enhancer of zeste homolog 2. Cells that are derived from these patient tumors provide an opportunity to expand our current knowledge regarding how these cells survive and the mechanisms that regulate their proliferation.<br />Summary: Understanding the mechanisms of highly invasive and therapy resistant prostate cancer cells resides in understanding the CSCs, which facilitate cancer recurrence. Some of these factors are just emerging and provide a platform for developing targeted drugs for the future treatment of advanced prostate cancer.

Details

Language :
English
ISSN :
1531-703X
Volume :
26
Issue :
3
Database :
MEDLINE
Journal :
Current opinion in oncology
Publication Type :
Academic Journal
Accession number :
24651383
Full Text :
https://doi.org/10.1097/CCO.0000000000000080